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Pancreatic islet preparations show enhanced glucose-stimulated insulin secretion compared to mono-agonists

The inhibition of LOX enzymes, especially 5-LOX, has shown promise as a therapy for anti-inflammatory and anti-cancer effects

In the endothelium, G6PD activity plays a key role in mediating endothelial cell homeostasis and VEGF-mediated angiogenesis (104), as depletion of enzyme activity is associated with decreased endothelial NOS activity and decreased NO bioavailability